Sodium Sulfate → 2-Amino-5-bromo-4-methoxybenzaldehyde

HRID 56482

반응식

HRID 56482 반응식
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Br:12]N1C(=O)CCC1=O.S([O-])([O-])(=O)=O.[Na+].[Na+]>ClCCl.O>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

6

반응물 3

HCID 24436Sodium SulfateHCID 67184N-bromobutanimideHCID 3235032-Amino-4-methoxybenzaldehyde

생성물 1

HCID 593252582-Amino-5-bromo-4-methoxybenzaldehyde수율 56%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231, found: 230, 232 [M+H]+.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1203a7025ae741efb01dce4fb28ead02
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434700B2

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