Sodium Hydroxide → 1-methylindole-2,7-dicarboxylic Acid

HRID 564977노트

반응식

HRID 564977 반응식
[C:1]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:13]=1[N:12]([CH3:14])[C:11]([C:15]([O:17]CC)=[O:16])=[CH:10]2)([O:3]C)=[O:2].[OH-].[Na+]>C(O)C>[CH3:14][N:12]1[C:13]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[C:1]([OH:3])=[O:2])[CH:10]=[C:11]1[C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10825291Ethyl 7-carbomethoxy-1-methyl-2-indolecarboxylate

생성물 1

HCID 108465121-methylindole-2,7-dicarboxylic Acid수율 107.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5.20 g (19.9 mmol) of ethyl 7-carbomethoxy-1-methyl-2-indolecarboxylate, 90 ml of 2N sodium hydroxide and 150 ml of ethanol was refluxed for 3 hours. The reaction mixture was concentrated under reduced pressure and ice water was added to the residue. 2N hydrochloric acid was added to acidify the reaction mixture. The precipitated solid was filtered and dried under reduced pressure to give 4.70 g (>99%) of 1-methylindole-2,7-dicarboxylic acid.

후처리

  1. temperaturewas refluxed for 3 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure and ice water
  3. additionwas added to the residue
  4. addition2N hydrochloric acid was added
  5. filtrationThe precipitated solid was filtered
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-c9a35eb550b0418a8322db2637d2740d
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169107A

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