Citric Acid → (r)-3-Triisopropylsilyloxybutyric acid

HRID 565436노트

반응식

HRID 565436 반응식
[CH:1]([Si:4]([CH:17]([CH3:19])[CH3:18])([CH:14]([CH3:16])[CH3:15])[O:5][C@H:6]([CH3:13])[CH2:7][C:8]([O:10]CC)=[O:9])([CH3:3])[CH3:2].[OH-].[Li+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O1CCCC1.O>[CH:17]([Si:4]([CH:1]([CH3:3])[CH3:2])([CH:14]([CH3:16])[CH3:15])[O:5][C@H:6]([CH3:13])[CH2:7][C:8]([OH:10])=[O:9])([CH3:18])[CH3:19]

참가 물질

5

반응물 3

HCID 311Citric AcidHCID 3939Lithium HydroxideHCID 54538409Ethyl (r)-(-)-3-triisopropylsilyloxybutyrate

생성물 1

HCID 14084664(r)-3-Triisopropylsilyloxybutyric acid

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

0.0755 mol (21.78 g) of the product from stage 1 is stirred at 60° C. for 5 days in 1.51 liters of a 0.01 molar lithium hydroxide solution in a tetrahydrofuran/water 1:1 mixture. The mixture is acidified with aqueous citric acid and the product is extracted with ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and concentrated under reduced pressure.

후처리

  1. extractionthe product is extracted with ethyl acetate
  2. washThe organic phase is washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b398b45452414ecaa579b9b8a5db52df
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172103B2

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