Water → 4,4-Diphenylbutan-1-ol

HRID 565650노트

반응식

HRID 565650 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([CH:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:14][CH2:15][C:16](O)=[O:17])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O.[OH-].[Na+]>C(OCC)C>[C:19]1([CH:13]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:14][CH2:15][CH2:16][OH:17])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 2743834,4-Diphenylbutanoic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 925194,4-Diphenylbutan-1-ol수율 99.1%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

In 70 mL of ice-cooled diethyl ether was suspended 1.9 g of lithium aluminum hydride, followed by dropwise addition of a solution of 4,4-diphenylbutyric acid (6.0 g) in diethyl ether (50 mL). After completion of dropwise addition, the mixture was refluxed for 2 hours and, then, allowed to cool. To this reaction mixture, 1.9 mL of water, 1.9 mL of 15% aqueous sodium hydroxide, and 5.7 mL of water were added in the order mentioned and the mixture was stirred at room temperature for 30 minutes. The precipitate was filtered off and the filtrate was concentrated to provide 5.6 g of the title compound. Yield 99%.

후처리

  1. additionAfter completion of dropwise addition
  2. temperaturethe mixture was refluxed for 2 hours
  3. temperatureto cool
  4. filtrationThe precipitate was filtered off
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-70974a9ac1214b46ae7221f29d3a0010
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172085B2

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