Water → 4,4-Diphenylbutyl methanesulfonate

HRID 565651노트

반응식

HRID 565651 반응식
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>ClC(Cl)C.C(N(CC)CC)C>[CH3:19][S:20]([O:11][CH2:10][CH2:9][CH2:8][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)(=[O:22])=[O:21]

참가 물질

6

반응물 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 925194,4-Diphenylbutan-1-ol

생성물 1

HCID 138807014,4-Diphenylbutyl methanesulfonate수율 99%

시약·촉매·용매 2

HCID 63651,1-Dichloroethane용매HCID 8471Triethylamine용매

실험 절차

To an iced-cooled solution of 4,4-diphenyl-1-butanol (5.6 g) in dichloroethane (100 mL), 11 mL of triethylamine and 2.9 mL of methanesulfonyl chloride were added dropwise in the order mentioned. After 30 minutes of stirring, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with saturated aqueous NaCl, dried over MgSO4, and concentrated to provide 7.5 g of the title compound. Yield 99%.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated aqueous NaCl
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c9ddfde998e143e8bc06e50cd97540c8
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06172085B2

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