(4-Pentyl-1-cyclohexenyl)-3,5-difluorobenzene → (4-Pentyl-cyclohexyl)-3,5-difluorobenzene

HRID 566158노트

반응식

HRID 566158 반응식
[CH2:1]([CH:6]1[CH2:11][CH2:10][C:9]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)=[CH:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[H][H]>[Ni].[C].[Pd]>[CH2:1]([CH:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 2

HCID 21265324(4-Pentyl-1-cyclohexenyl)-3,5-difluorobenzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22242488(4-Pentyl-cyclohexyl)-3,5-difluorobenzene수율 91%

시약·촉매·용매 2

HCID 935Nickel촉매2회HCID 178418390HCID 178418390, 화합물촉매

실험 절차

Mixture of (4-pentyl-1-cyclohexenyl)-3,5-difluorobenzene (89 mmol), Raney nickel (3.5 g), and 500 ml of Solmix was subjected to a hydrogenation reaction at room temperature under normal pressure for 10 hours. At the time when the amount of hydrogen has come not to further reduce and the reaction has come not to progress, catalyst was changed from Raney nickel to palladium carbon (2.4 g), and stirred for 8 hours. Palladium carbon was filtered off and the solvent was distilled off. The residue was purified by column chromatography (eluent: heptane) to give a (4-pentyl-cyclohexyl)-3,5-difluorobenzene (81 mmol).

후처리

  1. customwas subjected to a hydrogenation reaction at room temperature under normal pressure for 10 hours
  2. filtrationPalladium carbon was filtered off
  3. distillationthe solvent was distilled off
  4. customThe residue was purified by column chromatography (eluent: heptane)

출처 및 근거

ORD 기록
ord-d79e2e89be8f4e63859aa237b0ae9ac1
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06174458B1

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