Sodium Methoxide → 2-(6-Amino-2-pyridyl)ethanethiol

HRID 566242노트

반응식

HRID 566242 반응식
C([S:4][CH2:5][CH2:6][C:7]1[N:12]=[C:11]([NH2:13])[CH:10]=[CH:9][CH:8]=1)(=O)C.C[O-].[Na+]>CO.Cl>[NH2:13][C:11]1[N:12]=[C:7]([CH2:6][CH2:5][SH:4])[CH:8]=[CH:9][CH:10]=1

참가 물질

5

반응물 2

HCID 10942334Sodium MethoxideHCID 212658556-(2-Acetylthioethyl)-2-pyridylamine

생성물 1

HCID 212657842-(6-Amino-2-pyridyl)ethanethiol

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매2회

실험 절차

6-(2-Acetylthioethyl)-2-pyridylamine (0.56 g) was dissolved in methanol (10 ml). To the solution was added, at 0° C., sodium methylate (a 4.9N methanol solution, 0.58 ml), and the mixture was stirred for 30 minutes. To the reaction mixture was added iN hydrochloric acid (2.85 ml), followed by concentration under reduced pressure. To the concentrate was added ethyl acetate (10 ml), which was subjected to extraction. The extract solution was dried over anhydrous magnesium sulfate, followed by concentration to leave the title compound as an oily product (0.43 g).

후처리

  1. additionTo the solution was added, at 0° C.
  2. concentrationfollowed by concentration under reduced pressure
  3. additionTo the concentrate was added ethyl acetate (10 ml), which
  4. extractionwas subjected to extraction
  5. dry with materialThe extract solution was dried over anhydrous magnesium sulfate
  6. concentrationfollowed by concentration

출처 및 근거

ORD 기록
ord-96f7ca40286f450c9f28596ebf21dfb0
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06174877B1

반응 노트

불러오는 중…