Water → HCID 21265864, 화합물

HRID 566255노트

반응식

HRID 566255 반응식
[CH:1]1[N:2]=[C:3]([CH2:10][C:11](OC)=[O:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[BH4-].[Na+].O>CO>[CH:1]1[N:2]=[C:3]([CH2:10][CH2:11][OH:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 21265856HCID 21265856, 화합물

생성물 1

HCID 21265864HCID 21265864, 화합물수율 88.1%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

Methyl 2-(imidazo[1,5-a]pyridin-3-yl)acetate (1.85 g) was dissolved in methanol (30 ml). To the solution was added sodium borohydride (3.68 g), and the mixture was stirred for one hour at 60° C. To the reaction mixture was added water (20 ml), which was concentrated under reduced pressure. The concentrate was subjected to extraction twice with ethyl acetate (40 ml). The organic layers were combined and dried over anhydrous magnesium sulfate, followed by concentration to afford the title compound (1.39 g).

후처리

  1. concentrationwas concentrated under reduced pressure
  2. extractionThe concentrate was subjected to extraction twice with ethyl acetate (40 ml)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationfollowed by concentration

출처 및 근거

ORD 기록
ord-8bb3c0dc0e4743dfb19d1f1c560f125f
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06174877B1

반응 노트

불러오는 중…