Acetic Anhydride → 6-(5-Methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-one

반응식

N1[C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=N1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[CH3:18][C:17]1[O:19][C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=1

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 178518713HCID 178518713, 화합물

생성물 1

HCID 1358174476-(5-Methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-one

실험 절차

6-(1,2,3,4-Tetrazol-5-yl)-pyrido[3,4-d]pyrimidin-4-one (1.4 g) in acetic anhydride (10 ml) was heated at reflux under N2 for 2.5 hours. The cooled mixture was absorbed onto silica and purified by chromatography to give the title compound 90.14 g) as a beige solid; δH [2H6]DMSO 13.0(1H,bs), 9.30 (1H,s), 8.66 (1H,s), 8.47 (1H,s) 2.75 (3H,s); m/z (M+1+)230.

후처리

temperatureat reflux under N2 for 2.5 hours
customThe cooled mixture was absorbed onto silica
custompurified by chromatography

출처 및 근거

ORD 기록: ord-559d1d2348d94bf3a8cbb08d9107386b
출처 데이터셋: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06174889B1

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