Methyl L-phenylalaninate hydrochloride → HCID 86756228, 화합물

HRID 566414노트

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HRID 566414 반응식
[Cl:1][C:2]1[C:3]([OH:13])=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[OH:11])[C:5]([OH:7])=O.Cl.[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH2:19].CCN=C=N[CH2:33][CH2:34][CH2:35][N:36]([CH3:38])C.Cl.[CH:40]1C=CC2N(O)N=NC=2C=1>CN(C=O)C.C(N(CC)CC)C>[ClH:1].[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:19][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([Cl:12])[C:10]([O:11][CH2:40][CH2:33][CH2:34][CH2:35][NH:36][CH3:38])=[C:2]([Cl:1])[C:3]=1[OH:13]

참가 물질

7

반응물 4

HCID 75736Methyl L-phenylalaninate hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 3042133beta-Resorcylic acid, 3,5-dichloro-

생성물 1

HCID 86756228HCID 86756228, 화합물수율 95%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

To a solution of 3,5-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, Step 5) to give the title compound (18.32 g, yield 57%).

후처리

  1. additionThen, the mixture was post-treated in the same manner as in the above Example 1, Step 5)

출처 및 근거

ORD 기록
ord-085fae59107b4fb8a96c6fe0afb59b3b
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06174887B1

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