Einecs 211-027-4 → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one

반응식

[Cl:1][C:2]1[C:3]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[CH:17]([F:19])[F:18])=[CH:4][C:5]([O:8]C)=[N:6][CH:7]=1.[Cl-].[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[C:3]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[CH:17]([F:19])[F:18])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1

참가 물질

반응물 2

HCID 69401Einecs 211-027-4

HCID 1176048255-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine

생성물 1

HCID 1176055865-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one

실험 절차

305 mg (purity 77%, 0.77 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine and 20 eq. of pyridinium chloride were reacted according to General Method 3A. After work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 179 mg (80% of theory)

후처리

customAfter work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)

출처 및 근거

ORD 기록: ord-b098b5f42e87484490369782a0a6d1f2
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09434690B2

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