Benzoic Acid → HCID 21264391, 화합물

HRID 567098노트

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HRID 567098 반응식
[C:1](O)(=[O:8])[C:2]1[CH:7]=[CH:6]C=[CH:4][CH:3]=1.[OH:10]N1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.[CH2:32]([N:34]([CH2:37][CH3:38])[CH2:35][CH3:36])[CH3:33].[Cl:39][C:40]1[CH:45]=[CH:44][C:43]([CH:46]2[C:51]3[CH:52]=[CH:53][S:54][C:50]=3[CH2:49][CH2:48][NH:47]2)=[CH:42][CH:41]=1.CN(C)[CH:57]=[O:58]>C(OCC)(=O)C.O>[Cl:39][C:40]1[CH:41]=[CH:42][C:43]([CH:46]2[C:51]3[CH:52]=[CH:53][S:54][C:50]=3[CH2:49][CH2:48][N:47]2[C:1]([C:2]2[CH:7]=[CH:6][C:57]([O:58][CH2:33][CH2:32][N:34]3[CH2:37][CH2:38][O:10][CH2:36][CH2:35]3)=[CH:4][CH:3]=2)=[O:8])=[CH:44][CH:45]=1

참가 물질

9

반응물 6

HCID 243Benzoic AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27392694-(4-Chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

생성물 1

HCID 21264391HCID 21264391, 화합물수율 66%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

The above benzoic acid (111 mg, 0.38 mmoles) was suspended in N,N-dimethylformamide (1 mL). 1-Hydroxybenzotriazole (55 mg, 0.42 mmoles), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (79 mg, 0.42 mmoles), and triethylamine (106 μL, 0.76 mmoles) were added and the resulting mixture was shaken at 1000 rpm for 1.5 hour. 4-(4-Chlorophenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (100 mg, 0.38 mmoles) was added and the resulting mixture was shaken at 1000 rpm for 3 hours. Water (2 mL) and ethyl acetate (1 mL) were added and the resulting mixture was shaken at 1000 rpm for 15 minutes, The organic phase was evaporated to afford 122 mg (66%) of the title compound as an oil.

후처리

  1. stirringthe resulting mixture was shaken at 1000 rpm for 3 hours
  2. stirringthe resulting mixture was shaken at 1000 rpm for 15 minutes
  3. customThe organic phase was evaporated

출처 및 근거

ORD 기록
ord-77f0b759333f480e8ab6755fabad7b13
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06177443B1

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