2-Bromopropionic acid → 2-[4-(5-Chloro-2-cyanophenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoic acid

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:17]#[N:18])=[C:6]([C:8]2[C:9]([C:15]#[N:16])=[CH:10][NH:11][C:12](=[O:14])[CH:13]=2)[CH:7]=1.Br[CH:20]([CH3:24])[C:21]([OH:23])=[O:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:17]#[N:18])=[C:6]([C:8]2[C:9]([C:15]#[N:16])=[CH:10][N:11]([CH:20]([CH3:24])[C:21]([OH:23])=[O:22])[C:12](=[O:14])[CH:13]=2)[CH:7]=1

참가 물질

반응물 2

HCID 117292-Bromopropionic acid

HCID 1176056654-(5-Chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile

생성물 1

HCID 1176227652-[4-(5-Chloro-2-cyanophenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoic acid

실험 절차

312 mg (purity 91%, 1.11 mmol) of 4-(5-chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 45° C. Yield: 240 mg (purity 85%, 56% of theory)

후처리

customaccording to General Method 4A at 45° C

출처 및 근거

ORD 기록: ord-18db1e831c1f4d97889247fdc84cacdc
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09434690B2

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