1-Dodecanethiol → 1,3-Bis(dodecylsulfanyl)propan-2-ol

HRID 567186노트

반응식

HRID 567186 반응식
[CH2:1]([SH:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[Na].[CH2:15]([CH:17]1[O:19][CH2:18]1)Br>C(O)C.CCOCC>[CH2:1]([S:13][CH2:15][CH:17]([OH:19])[CH2:18][S:13][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

6

반응물 3

HCID 81951-DodecanethiolHCID 18430EpibromohydrinHCID 5360545Sodium

생성물 1

HCID 158395031,3-Bis(dodecylsulfanyl)propan-2-ol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

26.6 ml Dodecanethiol was added to an ethylate solution of 2.6 g sodium in 100 ml ethanol and the solution was stirred for 1 hour at room temperature. Then 8.5 ml epibromohydrin was added dropwise within 30 min and stirred overnight. The residue was taken up in ether after removing the solvent, washed twice with water and dried. The desired compound crystallized on evaporation of the solution. Yield 28.5 g (62%).

후처리

  1. stirringstirred overnight
  2. customafter removing the solvent
  3. washwashed twice with water
  4. customdried
  5. customThe desired compound crystallized on evaporation of the solution

출처 및 근거

ORD 기록
ord-9056b7813aa146589d3b2174d64054f7
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06177469B1

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