Phosphorus tribromide → 2-Benzyl benzylbromide

HRID 567288노트

반응식

HRID 567288 반응식
P(Br)(Br)[Br:2].[CH2:5]([C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14]O)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(Cl)(Cl)(Cl)Cl>[CH2:5]([C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14][Br:2])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 741092-Benzylbenzyl alcohol

생성물 1

HCID 124220982-Benzyl benzylbromide수율 99.7%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매2회

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온도
0 °C

실험 절차

A solution of phosphorus tribromide (2.1 mL, 6.0 g, 22.1 mM) in 30 mL of carbon tetrachloride was slowly added dropwise to solution of 2-benzylbenzyl alcohol (1.98 g, 10 mM) in 70 mL of carbon tetrachloride at 0° C. The mixture was stirred at 0° C. for 2 hours, then at room temperature for 2 hours. The solvent was removed in vacuo and the residue diluted with ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was washed with brine, dried over magnesium sulfate, filtered, and concentrated to afford 2.6 g (99%) of 2-benzylbenzyl bromide as a yellow solid. 1H NMR (DMSO-d6) δ 7.5-7.0 (m, 9H), 4.7 (s, 2H), and 4.15 (s, 2H). IR (CHCl3, cm−1) 3065, 1601, 1495, and 1453. MS (FD) m/e 260, 262.

후처리

  1. waitat room temperature for 2 hours
  2. customThe solvent was removed in vacuo
  3. additionthe residue diluted with ethyl acetate and saturated aqueous sodium bicarbonate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fcdff1ad71e84b49b2dec0387eb05836
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06177440B1

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