Sodium Hydroxide → HCID 3571815, 화합물

HRID 567711노트

반응식

HRID 567711 반응식
[OH-].[Na+].[OH:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:6][N:5]=1.[CH2:20]([NH:27][C:28](=[O:31])[CH2:29]Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(O)C>[O:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:6][N:5]1[CH2:29][C:28]([NH:27][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:31]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 145664Acetamide, N-benzyl-2-bromo-HCID 178518893HCID 178518893, 화합물

생성물 1

HCID 3571815HCID 3571815, 화합물수율 40.3%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

1N NaOH (4.5 mmol) is added to 1-hydroxy-4-phenyl-phthalazine (1 g, 4.5 mmol) in ethanol (20 ml). After 15 minutes, N-benzyl bromoacetamide (1.32 g, 4.5 mmol) is added, the reaction mixture is diluted with ethanol (20 ml) and is stirred overnight. Filtration followed by washing with ethanol (50 ml) and then with water (50 ml) yields the title compound (0.67 g). (R1=benzyl, R2=phenyl, A=benzene, Y1=—CH2—C(O)—NH—, m=0, p=0).

후처리

  1. filtrationFiltration
  2. washby washing with ethanol (50 ml)

출처 및 근거

ORD 기록
ord-3ff8728efe484c37b03399de0e07d243
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06180629B2

반응 노트

불러오는 중…