Formic Acid → Acetic anhydride formic acid

반응식

[CH:1]([OH:3])=[O:2].[C:4]([O:7][C:8](=[O:10])[CH3:9])(=[O:6])[CH3:5]>>[CH:1]([OH:3])=[O:2].[C:4]([O:7][C:8](=[O:10])[CH3:9])(=[O:6])[CH3:5]

참가 물질

반응물 2

HCID 284Formic Acid

HCID 7918Acetic Anhydride

생성물 1

HCID 19869020Acetic anhydride formic acid

반응 조건

온도: 50 °C

실험 절차

Formic acid (0.5 ml, 13.3 mmol) was added to acetic anhydride (1.0 ml, 10.6 mmol) under ice-cooling, the mixture was stirred for one hour at 50° C. to give formic acid-acetic acid anhydride. To a tetrahydrofuran (10 ml) solution of the compound 2 (200 mg, 0.34 mmol) obtained in Example 10 was added the formic acid-acetic acid anhydride (0.3 ml) under ice-is cooling and the mixture was stirred for 30 minutes. The mixture was stirred for one hour. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give colorless solid substance (125 mg) of the titled compound.

후처리

temperaturecooling

출처 및 근거

ORD 기록: ord-bd38bd8caf6544858811c5766937c057
출처 데이터셋: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06180792B2

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