Dabco → HCID 14099146, 화합물
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[N:4][CH:3]=1.N12CCN(CC1)CC2.[CH3:17][CH:18]([N:20]=[C:21]=[O:22])[CH3:19]>CN(C)C=O>[Cl:8][C:6]1[N:5]=[N:4][CH:3]=[C:2]([NH:1][C:21]([NH:20][CH:18]([CH3:19])[CH3:17])=[O:22])[CH:7]=1참가 물질
5
실험 절차
To a stirred solution of 0.8 gram of 4-amino-6-chloro-pyridazine in 30 ml of dimethylformamide is added 0.2 gram of 1,4-diazabicyclo[2.2.2]octane, followed by 0.6 gram of 1-methylethyl isocyanate. The reaction mixture is stirred at ambient temperature for 18 hours, then at 60° C. for six hours. The majority of the dimethylformamide is removed under reduced pressure, and the residue is slurried in water. The resultant solid is collected by filtration and dried to yield N-(6-chloro-4-pyridazinyl)-N'-(1-methylethyl)urea.
후처리
- waitat 60° C. for six hours
- customThe majority of the dimethylformamide is removed under reduced pressure
- filtrationThe resultant solid is collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-8c2dd2deef404a8cae116669538e97fa
- 출처 데이터셋
- uspto-grants-1988_03
- 특허 번호
- US04728355
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