Hydrazine Sulfate → 4,5-Dichloro-3-hydroxypyridazine

HRID 568306

반응식

HRID 568306 반응식
[C:1]([OH:9])(=O)/[C:2](=[C:4](\[CH:6]=O)/[Cl:5])/[Cl:3].S(O)(O)(=O)=O.[NH2:15][NH2:16].C([O-])(=O)C.[Na+]>O>[Cl:3][C:2]1[C:1](=[O:9])[NH:15][N:16]=[CH:6][C:4]=1[Cl:5]

참가 물질

5

반응물 3

HCID 24842Hydrazine SulfateHCID 517045Sodium AcetateHCID 2771871Mucochloric Acid

생성물 1

HCID 732474,5-Dichloro-3-hydroxypyridazine수율 78.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A stirred solution of 3.9 grams of mucochloric acid in water is warmed to 8°-100° C., and a mixture of 3.1 grams of hydrazine sulfate and 3.0 grams of sodium acetate is added. A solid is collected by filtration and recrystallized from water to yield 3.0 grams of 4,5-dichloro-3-pyridazone; m.p. 199°-200° C. The reaction is repeated several times.

후처리

  1. additionis added
  2. filtrationA solid is collected by filtration
  3. customrecrystallized from water

출처 및 근거

ORD 기록
ord-f4f8f537176043aabdaf384bca67c5bd
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04728355

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