N-methylcyclopentanamine → N-(4-pyridazinyl)-N'-cyclopentyl-N'-methylurea

HRID 568311

반응식

HRID 568311 반응식
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8](=[O:16])OC2C=CC=CC=2)=[CH:3][N:2]=1.[CH:17]1([NH:22][CH3:23])[CH2:21][CH2:20][CH2:19][CH2:18]1>O1CCCC1>[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([N:22]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH3:23])=[O:16])=[CH:3][N:2]=1

참가 물질

4

반응물 2

HCID 7020624N-methylcyclopentanamineHCID 14099147Phenyl pyridazin-4-ylcarbamate

생성물 1

HCID 20150035N-(4-pyridazinyl)-N'-cyclopentyl-N'-methylurea

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A stirred solution of 2.0 grams of phenyl N-(4-pyridazinyl)carbamate (prepared as in Example 2, Step A) and 0.9 gram of N-cyclopentyl-N-methyl amine in tetrahydrofuran is heated under reflux for 18 hours. The reaction mixture is filtered and the filtrate concentrated under reduced pressure to a residue. The residue is purified by column chromatography on silica gel to yield N-(4-pyridazinyl)-N'-cyclopentyl-N'-methylurea.

후처리

  1. temperatureunder reflux for 18 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate concentrated under reduced pressure to a residue
  4. customThe residue is purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-4f364a08bbb1497aba4f90badbd625b0
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04728355

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