Pyridinium chloride → 2,3-Dichloro-4-hydroxy-4'-fluorobenzophenone

HRID 568648

반응식

HRID 568648 반응식
[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([O:18]C)[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([OH:18])[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1)=[O:5]

참가 물질

3

반응물 2

HCID 10176127Pyridinium chlorideHCID 201506312,3-Dichloro-4-methoxy-4'-fluorobenzophenone

생성물 1

HCID 130157072,3-Dichloro-4-hydroxy-4'-fluorobenzophenone

반응 조건

온도
200 °C

실험 절차

A mixture of 39.5 g of 2,3-dichloro-4-methoxy-4'-fluorobenzophenone and 160 g of pyridine hydrochloride is heated at 200° C. for one hour. The reaction mixture is poured into ice water with stirring and a precipitate forms. The precipitate is filtered and dried for about 18 hours to yield 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone.

후처리

  1. filtrationThe precipitate is filtered
  2. customdried for about 18 hours

출처 및 근거

ORD 기록
ord-141736b1040f4f7890ebde6cb00d9c9d
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04728662

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