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Nitrogen → 7-Chloro-3-(2,3-difluorophenyl)-6-methoxy-1,2-benzisoxazole

HRID 568663
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인쇄 미리보기

반응식

HRID 568663 반응식
[H-].[Na+].C(O/[N:7]=[C:8](/[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[F:26])\[C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([Cl:17])[C:10]=1[OH:18])(=O)C.N#N.O>CN(C=O)C>[Cl:17][C:11]1[C:10]2[O:18][N:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=3[F:26])[C:9]=2[CH:14]=[CH:13][C:12]=1[O:15][CH3:16]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 947NitrogenHCID 962WaterHCID 24758Sodium hydrideHCID 136477386[(E)-[(3-chloro-2-hydroxy-4-methoxyphenyl)-(2,3-difluorophenyl)methylidene]amino] acetate

생성물 1

HCID 140124987-Chloro-3-(2,3-difluorophenyl)-6-methoxy-1,2-benzisoxazole

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매
2회

반응 조건

온도
45 °C

실험 절차

To a mixture of 1.4 g of NaH in 200 ml of DMF, a solution of 19 g of E-3-chloro-2',3'-difluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime in 200 ml of DMF is added dropwise in an atmosphere of N2. The mixture is stirred for one half hour and then warmed at 45° C. for one half hour. Water is added and a product precipitates and is filtered and dried giving 7-chloro-3-(2,3-difluorophenyl)-6-methoxy-1,2-benzisoxazole, mp 184°-189° C.

후처리

  1. customa product precipitates
  2. filtrationis filtered
  3. customdried

출처 및 근거

ORD 기록
ord-d15a806a1c544e8691727a6a8156f668
출처 데이터셋
uspto-grants-1988_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04728662

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