3-Butyn-1-OL → HCID 20071329, 화합물
반응식
[CH2:1]([OH:5])[CH2:2][C:3]#[CH:4].Br[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[OH-].[Na+]>O>[CH2:1]([O:5][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:2][C:3]#[CH:4]참가 물질
5
실험 절차
A mixture of 3-butyn-1-ol (5.0 g), (4-bromobutyl)benzene (15.0 g), aqueous sodium hydroxide (30 ml, 50% w/v), and TAB (0.6 g) was stirred vigorously for 3 days, treated with water (100 ml) and extracted with ER (2×200 ml). The dried extract was evaporated and the residue was purified by FCC eluting with CX-ER 19:1 to give the title compound as a colourless oil (9.5 g). T.l.c. (CX-ER 9:1) Rf 0.45.
후처리
- extractionextracted with ER (2×200 ml)
- extractionThe dried extract
- customwas evaporated
- customthe residue was purified by FCC
- washeluting with CX-ER 19:1
출처 및 근거
- ORD 기록
- ord-cf12bc80e9034667a9e30d1e82bc528e
- 출처 데이터셋
- uspto-grants-1988_03
- 특허 번호
- US04730008
반응 노트
불러오는 중…