Phthalimide → HCID 20149445, 화합물

HRID 568987노트

반응식

HRID 568987 반응식
O[CH:2]([CH2:5][CH2:6][C:7]([F:23])([F:22])[CH:8]([N:11]1[C:15](=[O:16])[C:14]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]2[C:12]1=[O:21])[CH:9]=[CH2:10])[CH:3]=[CH2:4].[C:24]1(=[O:34])[NH:28][C:27](=[O:29])[C:26]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:25]12.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[C:24]1(=[O:34])[N:28]([CH:2]([CH2:5][CH2:6][C:7]([F:23])([F:22])[CH:8]([N:11]2[C:15](=[O:16])[C:14]3=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]3[C:12]2=[O:21])[CH:9]=[CH2:10])[CH:3]=[CH2:4])[C:27](=[O:29])[C:26]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:25]12

참가 물질

6

반응물 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 20149486HCID 20149486, 화합물

생성물 1

HCID 20149445HCID 20149445, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 3-hydroxy-6,6-difluoro-7-phthalimido-1,8-nonadiene (148 mg, 0.46 mmoles), phthalimide (73.5 mg, 0.5 mmoles), triphenylphosphine (131.5 mg, 0.5 mmoles) and diethyl azodicarboxylate (73 l, 0.6 mmoles) in tetrahydrofuran (5 ml) is kept under nitrogen at 25° C. for 20 hours. After concentration under reduced pressure, the title compound is obtained after purification by chromatography on silica (dichloromethane, RF: 0.43): 95 mg (46%).

후처리

  1. concentrationAfter concentration under reduced pressure

출처 및 근거

ORD 기록
ord-f32b1760e7c0413f85497921899d8062
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04730006

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