Ethanol → 1-Chloro-5-(4-chlorophenoxy)-3,3-dimethylpentan-2-one

HRID 569199노트

반응식

HRID 569199 반응식
[Cl:1][C:2](OC1C=CC(Cl)=CC=1)=[CH:3][C:4]([CH3:16])([CH3:15])[CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.C([OH:27])C>Cl>[Cl:1][CH2:2][C:3](=[O:27])[C:4]([CH3:16])([CH3:15])[CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 702EthanolHCID 54255953HCID 54255953, 화합물

생성물 1

HCID 133228741-Chloro-5-(4-chlorophenoxy)-3,3-dimethylpentan-2-one수율 88%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

580 g (1.5 mols) of 1-chloro-3,3-dimethyl-1,5-di-(4-chlorophenoxy)-1-pentene in 1,000 ml of ethanol and 300 ml of concentrated hydrochloric acid are heated under reflux for 4 hours. The ethanol is removed in vacuo, and the residue is diluted with methylene chloride and extracted by shaking with water, and then three times with dilute sodium hydroxide solution. The dried solution is freed of solvent in vacuo. 363 g (88% of theory) of 1-chloro-5-(4-chlorophenoxy)-3,3-dimethyl-2-pentanone are obtained as an oil.

후처리

  1. temperatureunder reflux for 4 hours
  2. customThe ethanol is removed in vacuo
  3. additionthe residue is diluted with methylene chloride
  4. extractionextracted

출처 및 근거

ORD 기록
ord-d66122ce2dde4cf5be909e71f315066e
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04731452

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