Succinic anhydride → 2-(3-Methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylic acid

HRID 569237

반응식

HRID 569237 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[CH:6]=[N:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:17]1(=[O:23])[O:22][C:20](=[O:21])[CH2:19][CH2:18]1>C1(C)C(C)=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]2[CH:19]([C:20]([OH:22])=[O:21])[CH2:18][C:17](=[O:23])[N:7]2[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 7922Succinic anhydrideHCID 555084N-(3-Methoxybenzylidene)aniline

생성물 1

HCID 133619852-(3-Methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylic acid

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A solution of 42.3 gm. of 3-methoxybenzylidenaniline, 20 gm. of succinic anhydride and 200 ml. of xylene was refluxed for 16 hours. The crude product was obtained as a solid via the same workup used for example 1B. Recrystallization from ethyl acetate followed by a second recrystallization from acetonitrile provided 21.0 gm. of colorless crystals, m.p. 145°-149°.

출처 및 근거

ORD 기록
ord-8ac826c538a24c5ca9b68e7c1c721d98
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04731457

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