Tetraethyl (phenoxymethylene)-bisphosphonate → (Phenoxymethylene)-bisphosphonic acid
반응식
[O:1]([CH:8]([P:17](=[O:24])([O:21]CC)[O:18]CC)[P:9](=[O:16])([O:13]CC)[O:10]CC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[O:1]([CH:8]([P:17](=[O:18])([OH:21])[OH:24])[P:9](=[O:10])([OH:13])[OH:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
3
실험 절차
A mixture of tetraethyl (phenoxymethylene)-bisphosphonate (20 g) and 6N hydrochloric acid (150 ml) was refluxed overnight and the resulting solution was evaporated to dryness in vacuo. Residual hydrochloric acid was removed by repeated evaporation with absolute ethanol. The residue was taken up in acetone (7 ml) and ether (200 ml) was added. The crystalline product was filtered, washed with ether and dried in vacuo.
후처리
- temperaturewas refluxed overnight
- customthe resulting solution was evaporated to dryness in vacuo
- customResidual hydrochloric acid was removed
- customevaporation with absolute ethanol
- additionether (200 ml) was added
- filtrationThe crystalline product was filtered
- washwashed with ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-fed28e7d18344f6e97ba7c2d9727c9ab
- 출처 데이터셋
- uspto-grants-1988_03
- 특허 번호
- US04732998
반응 노트
불러오는 중…