Diisobutylaluminum hydride → (1H-indol-5-yl)methanol

HRID 569739

반응식

HRID 569739 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10](OC)=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.CC(C[AlH]CC(C)C)C>CCOCC>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][OH:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 14487Diisobutylaluminum hydrideHCID 2737635methyl 1H-indole-5-carboxylate

생성물 1

HCID 2773458(1H-indol-5-yl)methanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

96 g (0.548 mole) of 6b are treated analogously to Example 1a in 1,800 ml of ether and 1,391 ml (1.67 moles) of DIBAL (1.2 molar in toluene). After chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product are obtained. C9H9NO (147.2)

후처리

  1. washAfter chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product
  2. customare obtained

출처 및 근거

ORD 기록
ord-bc1b83dde3684cc4aa27d378a6abf204
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734407

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