5-Amino-2-(trifluoromethyl)benzimidazole → 2-[5-Chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-N-[2-(trifluoromethyl)-1H-benzimidazol-6-yl]propanamide
반응식
[Cl:1][C:2]1[C:3]([C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[C:21]#[N:22])=[CH:4][C:5](=[O:13])[N:6]([CH:8]([CH3:12])[C:9]([OH:11])=O)[CH:7]=1.[F:23][C:24]([F:36])([F:35])[C:25]1[NH:29][C:28]2[CH:30]=[C:31]([NH2:34])[CH:32]=[CH:33][C:27]=2[N:26]=1>>[Cl:1][C:2]1[C:3]([C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[C:21]#[N:22])=[CH:4][C:5](=[O:13])[N:6]([CH:8]([CH3:12])[C:9]([NH:34][C:31]2[CH:32]=[CH:33][C:27]3[N:26]=[C:25]([C:24]([F:36])([F:35])[F:23])[NH:29][C:28]=3[CH:30]=2)=[O:11])[CH:7]=1참가 물질
3
실험 절차
68 mg (purity 94%, 0.20 mmol) of 2-[5-chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) (Example 12.1D) and 44 mg (0.22 mmol) of 2-(trifluoromethyl)-1H-benzimidazole-6-amine were reacted according to General Method 1. Yield: 63 mg (60% of theory)
출처 및 근거
- ORD 기록
- ord-6aac64e77c8e422fbbcd7cb55ae1e4d2