Dimethylformamide dimethyl acetal → HCID 54034117, 화합물

반응식

[CH3:1][N:2]1[C:6]2[CH2:7][CH2:8][CH2:9][C:10](=[O:12])[CH2:11][C:5]=2[CH:4]=[N:3]1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>>[CH3:15][N:16]([CH:18]=[C:11]1[C:5]2[CH:4]=[N:3][N:2]([CH3:1])[C:6]=2[CH2:7][CH2:8][CH2:9][C:10]1=[O:12])[CH3:17]

참가 물질

반응물 2

HCID 78373Dimethylformamide dimethyl acetal

HCID 20146582HCID 20146582, 화합물

생성물 1

HCID 54034117HCID 54034117, 화합물

실험 절차

A mixture of 27.6 g of 4,6,7,8-tetrahydro-1-methyl-5(1H)-cycloheptapyrazolone and 100 ml of N,N-dimethylformamide dimethyl acetal was heated at reflux for 1.5 hours. The solvent was then removed under reduced pressure and the residue was flash chromatographed (10% methanol in dichloromethane) to give 4-(dimethylaminomethylene)-4,6,7,8-tetrahydro-1-methyl-5(1H)-cycloheptapyrazolone.

후처리

temperaturewas heated
temperatureat reflux for 1.5 hours
customThe solvent was then removed under reduced pressure
customchromatographed (10% methanol in dichloromethane)

출처 및 근거

ORD 기록: ord-d4fa3f25531f4d0180b591339bf6ce33
출처 데이터셋: uspto-grants-1988_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04734429

반응 노트

불러오는 중…