Hydrochloric Acid → HCID 12899415, 화합물

반응식

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 12899414HCID 12899414, 화합물

생성물 1

HCID 12899415HCID 12899415, 화합물수율 78.2%

실험 절차

The thus-obtained 21 g of 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril are dispersed in 150 ml of 8N-hydrochloric acid. The dispersion is heated under reflux conditions for 3 hours and then cooled. Insoluble matter thus formed is separated by filtration, washed with water and dried, and recrystallized from methanol-water to obtain 14 g of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 212°-213° C.

후처리

temperatureThe dispersion is heated under reflux conditions for 3 hours
temperaturecooled
customInsoluble matter thus formed
customis separated by filtration
washwashed with water
customdried
customrecrystallized from methanol-water

출처 및 근거

ORD 기록: ord-5b284d439d07405a8c9d94bf80207417
출처 데이터셋: uspto-grants-1988_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04734416

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