Hydrochloric Acid → 1-Ethylpiperidine-2,4-dione

HRID 569989노트

반응식

HRID 569989 반응식
C([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][N:8]([CH2:13][CH3:14])[C:7]1=[O:15])(OCC)=O.Cl>>[CH2:13]([N:8]1[CH2:9][CH2:10][C:11](=[O:12])[CH2:6][C:7]1=[O:15])[CH3:14]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 13784118Ethyl 1-Ethyl-2,4-dioxopiperidine-3-carboxylate

생성물 1

HCID 137841191-Ethylpiperidine-2,4-dione수율 70%

실험 절차

Added to 36.0 g of 3-carboethoxy-1-ethylpiperidine-2,4-dione (Referential Example 35) was 300 ml of a 10% aqueous solution of hydrochloric acid. The resultant mixture was refluxed for 40 minutes. After allowing the reaction mixture to cool down, it was extracted with chloroform. The chloroform layer was washed with water, dried and then concentrated, thereby obtaining 16.6 g of 1-ethylpiperidine-2,4-dione as a light yellowish oily substance (yield: 70%).

후처리

  1. temperatureto cool down
  2. extractionit was extracted with chloroform
  3. washThe chloroform layer was washed with water
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-03264042118a435a924dd981a1008270
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734418

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