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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 57058생성일: 2026년 10월 27일

Lithium Hydroxide → 6-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/57058

반응식

참여 물질

역할이름HCID투입량
반응물Lithium HydroxideHCID 3939—
반응물Ethyl 6-({2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylateHCID 117622475—
생성물6-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylic acidHCID 117622918—

반응 단계

80 mg (135 μmol) of ethyl 6-({2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylate (racemate) were hydrolysed with lithium hydroxide at RT according to General Method 3. Yield: 63 mg (purity 90%, 74% of theory)

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09434690B2
출처 데이터셋uspto-grants-2016_09
ORD IDord-fcad36f0610f45c9b293400e464ea62d
출처 메모uspto-grants-2016_09