HRID57058

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOC(=O)c1cc2cc(OC)c(NC(=O)C(CCOC)n3cc(OC)c(-c4cc(Cl)ccc4C#N)cc3=O)cc2[nH]1

HCID117622475

未命名化合物

PRODUCTS

生成物

结构：COCCC(C(=O)Nc1cc2[nH]c(C(=O)O)cc2cc1OC)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O

HCID117622918

未命名化合物

PROCEDURE

实验过程

80 mg (135 μmol) of ethyl 6-({2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylate (racemate) were hydrolysed with lithium hydroxide at RT according to General Method 3. Yield: 63 mg (purity 90%, 74% of theory)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fcad36f0610f45c9b293400e464ea62d
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434690B2
来源说明: uspto-grants-2016_09

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:41]#[N:42])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:36][CH2:37][O:38][CH3:39])[C:17]([NH:19][C:20]3[CH:28]=[C:27]4[C:23]([CH:24]=[C:25]([C:29]([O:31]CC)=[O:30])[NH:26]4)=[CH:22][C:21]=3[O:34][CH3:35])=[O:18])[C:10](=[O:40])[CH:9]=2)[CH:7]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:41]#[N:42])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:36][CH2:37][O:38][CH3:39])[C:17]([NH:19][C:20]3[CH:28]=[C:27]4[C:23]([CH:24]=[C:25]([C:29]([OH:31])=[O:30])[NH:26]4)=[CH:22][C:21]=3[O:34][CH3:35])=[O:18])[C:10](=[O:40])[CH:9]=2)[CH:7]=1