Methyl iodide → Methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide

HRID 570940

반응식

HRID 570940 반응식
[CH3:1][N:2]1[C:7](=[O:8])[N:6]2[CH:9]=[N:10][C:11]([C:12](=[S:14])[NH2:13])=[C:5]2[N:4]=[N:3]1.[CH3:15][I:16]>C(#N)C>[IH:16].[CH3:1][N:2]1[C:7](=[O:8])[N:6]2[CH:9]=[N:10][C:11]([C:12]([S:14][CH3:15])=[NH:13])=[C:5]2[N:4]=[N:3]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 33528803-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide

생성물 1

HCID 66831606Methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide수율 88%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide (2.75 g, 13.1 mmol) and methyl iodide (8.2 mL, 131 mmol) in acetonitrile (900 mL) was stirred at room temperature for 3 days. The mixture was concentrated under vacuum and the solid was suspended in diethyl ether. The precipitate was filtered and washed with diethyl ether to give the pure title compound as an orange solid (4.03 g, 88% yield). δH (DMSO-d6): 11.6 (1H, bs), 9.18 (1H, s) 3.94 (3H, s), 2.82 (3H, s).

후처리

  1. concentrationThe mixture was concentrated under vacuum
  2. filtrationThe precipitate was filtered
  3. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-f5e14e63d54e413c89dae841aa3c9064
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024018B2

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