Hydrogen iodide → HCID 178481972, 화합물

HRID 570946노트

반응식

HRID 570946 반응식
I.[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13](=[NH:23])[NH:14][CH2:15][C:16](=O)[C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)=[C:6]2[N:5]=[N:4]1.I>Cl>[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13]3[NH:14][CH:15]=[C:16]([C:17]4[S:18][CH:19]=[CH:20][CH:21]=4)[N:23]=3)=[C:6]2[N:5]=[N:4]1

참가 물질

4

반응물 2

HCID 24841Hydrogen iodideHCID 1784819793-Methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide

생성물 1

HCID 178481972HCID 178481972, 화합물수율 89.3%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매2회

반응 조건

온도
80 °C

실험 절차

A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (40 mg) in 3N HCl (3 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give the a mixture of the hydrochloride and hydroiodide salts of the title compound (24 mg).

후처리

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

출처 및 근거

ORD 기록
ord-d4c1abc50713406798b58db77ffdaf53
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024018B2

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