N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide → N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide

HRID 571085노트

반응식

HRID 571085 반응식
[CH2:1]([C:5]1[O:6][C:7]2[CH:26]=[CH:25][C:24]([NH:27][S:28]([CH3:31])(=[O:30])=[O:29])=[CH:23][C:8]=2[C:9]=1[C:10](=[O:22])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][C:20]#[N:21])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH3:4]>CO.[Ni]>[CH2:1]([C:5]1[O:6][C:7]2[CH:26]=[CH:25][C:24]([NH:27][S:28]([CH3:31])(=[O:29])=[O:30])=[CH:23][C:8]=2[C:9]=1[C:10](=[O:22])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][NH2:21])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 66571290N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide

생성물 1

HCID 10095002N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

3.0 g of N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide is dissolved in 300 ml of methanol and 5 g of Raney-Ni catalyst is added. The mixture is stirred at 25° C. at 10 bar H2 pressure for 24 hours. The catalyst is filtered and the solvent is evaporated.

후처리

  1. filtrationThe catalyst is filtered
  2. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-f8b7e0945df943589bef364b82b1f117
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024046B2

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