Hydrochloric Acid → HCID 86681636, 화합물

HRID 571220노트

반응식

HRID 571220 반응식
C(OC([NH:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:10]=1)=O)(C)(C)C.[ClH:24].O1CCOCC1>C(Cl)Cl>[ClH:24].[NH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 866816351H-Indole-1-acetic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester

생성물 1

HCID 86681636HCID 86681636, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of ethyl 2-(3-(tert-butoxycarbonylamino)-1H-indol-1-yl)acetate (275 mg, 0.864 mmol) in dry DCM (8 ml), cooled at 0° C. and under nitrogen, 4N HCl in dioxane (2.159 ml, 8.64 mmol) was added, and the mixture was stirred at room temperature for 36 hours. The solvent was removed under reduced pressure without heating to give ethyl 2-(3-amino-1H-indol-1-yl)acetate hydrochloride (220 mg, 0.864 mmol, quantitative yield). MS/ESI+ 219.1 [MH]+.

후처리

  1. customThe solvent was removed under reduced pressure
  2. temperaturewithout heating

출처 및 근거

ORD 기록
ord-0ea932c3a3514d3f8ebba6a52bf77971
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024027B2

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