4,5-Dimethoxyphthalic acid → 5,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione

HRID 571273

반응식

HRID 571273 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:14]([OH:16])=[O:15])[C:6](=[CH:10][C:11]=1[O:12][CH3:13])[C:7]([OH:9])=O>C(OC(=O)C)(=O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:6]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[C:14](=[O:15])[O:16][C:7]2=[O:9]

참가 물질

3

반응물 1

HCID 2909884,5-Dimethoxyphthalic acid

생성물 1

HCID 6103565,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione수율 100%

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

반응 조건

온도
120 °C

실험 절차

A suspension of 4,5-dimethoxyphthalic acid (600 mg, 2.65 mmol) in acetic anhydride (5 ml) was heated to 120° C. for 1 hour. The solvent was then removed under vacuum to afford 5,6-dimethoxyisobenzofuran-1,3-dione as a yellow solid (552 mg, 2.65 mmol, quantitative yield). MS/ESI+ 208.9 [MH]+. This compound was used as such in the next step.

후처리

  1. customThe solvent was then removed under vacuum

출처 및 근거

ORD 기록
ord-a0158521a50f40928df4c262338ecd87
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024027B2

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