Acenaphthenequinone → 7,9-Diphenyl-8H-cyclopenta[a]acenaphthylen-8-one

HRID 571586

반응식

HRID 571586 반응식
[C:1]1(=O)[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH:6]=[CH:5][CH:4]=[C:3]3[C:2]1=O.[C:15]1([CH2:21][C:22](=[O:30])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[OH-].[K+]>C(O)C>[C:24]1([C:23]2[C:22](=[O:30])[C:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:2]3[C:3]4=[C:12]5[C:7](=[CH:6][CH:5]=[CH:4]4)[CH:8]=[CH:9][CH:10]=[C:11]5[C:1]=23)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

5

반응물 3

HCID 6724AcenaphthenequinoneHCID 75931,3-Diphenyl-2-propanoneHCID 14797Potassium Hydroxide2회

생성물 1

HCID 2671457,9-Diphenyl-8H-cyclopenta[a]acenaphthylen-8-one수율 71.3%

시약·촉매·용매 1

HCID 702Ethanol용매3회

실험 절차

An amount of 5.9 g (32.4 mmol) of acenaphthenequinone and 7.5 g (35.7 mmol) of 1,3-diphenyl-2-propanone were suspended in 150 ml of ethanol and a solution of 2 g of potassium hydroxide in ethanol was added. After the mixture was heated to the reflux temperature, the same amount of the solution of potassium hydroxide in ethanol was further added and allowed to react for five minutes. The solid substance deposited after cooled on ice was filtered and washed with ethanol to obtain 8.24 g (23.1 mmol) of 7,9-diphenylcyclopenta[a]acenaphthylene-8-one. The yield was 71.3%.

후처리

  1. temperatureAfter the mixture was heated to the reflux temperature
  2. customto react for five minutes
  3. temperatureThe solid substance deposited after cooled on ice
  4. filtrationwas filtered
  5. washwashed with ethanol

출처 및 근거

ORD 기록
ord-67ff0ccdf2d04779ba9e16d21b7f7d1e
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09028976B2

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