Acetic Acid → cis-3-(Boc-amino)-5-methylpiperidine
반응식
[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH:5]=[N:6][CH:7]=1.CC(O)=O>[Pt]>[CH3:1][C@@H:2]1[CH2:7][NH:6][CH2:5][C@H:4]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:3]1참가 물질
4
실험 절차
A Parr bottle was charged with tert-butyl 5-methylpyridin-3-ylcarbamate (365 mg, 1.75 mmol) and AcOH (10 mL, 0.17 mol). Nitrogen was bubbled through the mixture for several minutes with stirring before 5% Pt/C (365 mg, 0.027 mol) was added, and the bottle was placed under an atmosphere of hydrogen (60 psi) for 24 h. The mixture was filtered and the solvent concentrated in vacuo to afford the title intermediate as an oil, which was used without further purification.
후처리
- customNitrogen was bubbled through the mixture for several minutes
- additionwas added
- filtrationThe mixture was filtered
- concentrationthe solvent concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-b516faf86b614a5090383822fc37a2aa
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09029359B2
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