Dimethyl Sulfoxide → [4-(4-Benzyl-morpholin-2-yl)-phenyl]-(2,6-dimethyl-phenyl)-methanone

HRID 571782노트

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HRID 571782 반응식
C(Cl)(=O)C(Cl)=O.CS(C)=O.[CH2:11]([N:18]1[CH2:23][CH2:22][O:21][CH:20]([C:24]2[CH:29]=[CH:28][C:27]([CH:30]([C:32]3[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:33]=3[CH3:39])[OH:31])=[CH:26][CH:25]=2)[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CCN(CC)CC.[NH4+].[OH-]>C(Cl)Cl>[CH2:11]([N:18]1[CH2:23][CH2:22][O:21][CH:20]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([C:32]3[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:33]=3[CH3:39])=[O:31])=[CH:26][CH:25]=2)[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

7

반응물 5

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 14923Ammonium HydroxideHCID 65578Oxalyl chlorideHCID 66653558HCID 66653558, 화합물

생성물 1

HCID 66653880[4-(4-Benzyl-morpholin-2-yl)-phenyl]-(2,6-dimethyl-phenyl)-methanone수율 94.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
-78 °C

실험 절차

To a solution of oxalyl chloride (0.46 mL, 5.4 mmol) in CH2Cl2 (20 mL), was added dropwise DMSO (0.94 mL, 13.2 mmol), at −78° C. Subsequently, a solution of [4-(4-benzyl-morpholin-2-yl)-phenyl]-(2,6-dimethyl-phenyl)-methanol (1.6 g, 4.1 mmol) in CH2Cl2 (30 mL) was added, dropwise, at −78° C. After the addition was complete the mixture was stirred for 30 min., at −78° C., and then Et3N (2.9 mL, 20.8 mmol) was added. After complete addition the mixture was allowed to warm to room temperature, overnight. Next, a 2M aqueous NH4OH solution (30 mL) was added, and the mixture extracted with CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo to afford [4-(4-benzyl-morpholin-2-yl)-phenyl]-(2,6-dimethyl-phenyl)-methanone (1.5 g), which was used as such in the next step.

후처리

  1. customat −78° C
  2. customat −78° C
  3. additionAfter the addition
  4. additionAfter complete addition the mixture
  5. temperatureto warm to room temperature, overnight
  6. extractionthe mixture extracted with CH2Cl2
  7. dry with materialThe combined organic layers were dried (Na2SO4)
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4fe5b31e0c144ccfa480ff75df54ac30
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029371B2

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