Hydrazine hydrate (1:1) → HCID 178434638, 화합물

HRID 57238노트

반응식

HRID 57238 반응식
[Br:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]=[C:7]([C:9](=[C:12](OC)[CH3:13])[C:10]#[N:11])[S:8][C:4]=2[CH:3]=1.O.[NH2:19][NH2:20]>CO>[Br:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]=[C:7]([C:9]3[C:12]([CH3:13])=[N:20][NH:19][C:10]=3[NH2:11])[S:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 667681932-(6-Bromobenzothiazol-2-yl)-3-methoxybut-2-enenitrile

생성물 1

HCID 178434638HCID 178434638, 화합물수율 5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2-(6-bromobenzothiazol-2-yl)-3-methoxybut-2-enenitrile (0.96 g, 3.1 mmol) and hydrazine hydrate (0.3 mL, 5.4 mmol) in methanol (30 mL) was heated to reflux overnight. The reaction was then cooled to room temperature. The resulting solid was isolated by filtration and was purified by flash chromatography to yield the title product. MS (m/z, ES+): 308.9 (Br79M+1, 100%), 310.9 (Br81 M+1, 100%). Yield=5%.

후처리

  1. temperatureto reflux overnight
  2. customThe resulting solid was isolated by filtration
  3. customwas purified by flash chromatography

출처 및 근거

ORD 기록
ord-12b0a0ebb1254a1a950e98de787e1ebf
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434720B2

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