Hydrazine hydrate (1:1) → HCID 178434665, 화합물
반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10](=[C:13](OC)[CH3:14])[C:11]#[N:12])=[N:7][C:6]=2[CH:17]=1.O.[NH2:19][NH2:20]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10]3[C:13]([CH3:14])=[N:20][NH:19][C:11]=3[NH2:12])=[N:7][C:6]=2[CH:17]=1참가 물질
4
실험 절차
A suspension of 2-(5-fluorobenzothiazol-2-yl)-3-methoxybut-2-enenitrile (330 mg, 1.3 mmol) and hydrazine hydrate (70 μL) in methanol (40 mL) was heated to reflux overnight. The solution was then cooled to room temperature and the resulting solid was isolated by filtration. The crude material was recrystallized from ethanol to yield 260 mg (78%, 10% for five steps) of the title compound. MS (m/z, ES+): 249.0 (M+1,100%).
후처리
- temperaturewas heated
- temperatureto reflux overnight
- customthe resulting solid was isolated by filtration
- customThe crude material was recrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-38f641c1a68b4fb8b061aec3a7fef7fd
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434720B2
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