Dimethyl Carbonate → Methyl 2-(6-methoxypyridin-2-yl)acetate
반응식
[Li+].CC([N-]C(C)C)C.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1.[C:18](=O)([O:21]C)[O:19][CH3:20]>C1COCC1>[CH3:9][O:10][C:11]1[N:12]=[C:13]([CH2:17][C:18]([O:19][CH3:20])=[O:21])[CH:14]=[CH:15][CH:16]=1참가 물질
5
실험 절차
To the solution of LDA (18.3 mL, 36.5 mmol) in THF (120 mL) cooled to −78° C. was added 2-methoxy-6-methylpyridine (1.5 g, 12.2 mmol) in THF (15 mL) dropwise, and then the mixture was stirred at −78 degree for 2 h. Dimethyl carbonate (1.2 mL, 14.6 mmol) was added quickly and continued to stir at −78° C. for 15 min. The reaction was quenched by H2O at −78° C. The solution was extracted with ethyl acetate, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified with a standard method to give desired compound.
후처리
- stirringto stir at −78° C. for 15 min
- customThe reaction was quenched by H2O at −78° C
- extractionThe solution was extracted with ethyl acetate
- dry with materialdried over sodium sulfate
- customevaporated under reduced pressure
- customThe residue was purified with a standard method
출처 및 근거
- ORD 기록
- ord-4d14ca8d2b144a41b5c2a8fa87c5c1be
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09029531B2
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