Formaldehyde → Ethyl 2-(6-(dimethylamino)pyridin-2-yl)acetate
반응식
N[C:2]1[N:7]=[C:6]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:4][CH:3]=1.[CH2:14]=O.[BH3-][C:17]#[N:18].[Na+]>CO.CC(O)=O>[CH3:14][N:18]([CH3:17])[C:2]1[N:7]=[C:6]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:4][CH:3]=1참가 물질
6
실험 절차
To the solution of ethyl 2-(6-aminopyridin-2-yl)acetate (150 mg, 0.83 mmol) and paraformaldehyde (54.8 mg, 1.83 mmol) in methanol (6 mL) was added NaBH3CN (130.3 mg, 2.08 mmol) and AcOH (1 drop, cat.). The mixture was stirred at room temperature for 12 h. Then, the reaction was quenched with aqueous ammonium chloride and extracted with DCM. The organic layer was with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to get desired product (100 mg).
후처리
- customThen, the reaction was quenched with aqueous ammonium chloride
- extractionextracted with DCM
- dry with materialdried over sodium sulfate
- customevaporated under reduced pressure
- customThe residue was purified by a standard method
출처 및 근거
- ORD 기록
- ord-58578459920b401ea0f1152885408c78
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09029531B2
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