Potassium Phosphate, Tribasic → Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate

HRID 573095

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HRID 573095 반응식
F[C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([Cl:22])[CH:16]=1.[O-]P([O-])([O-])=O.[K+].[K+].[K+]>COCCOCCOC.C(OCC)(=O)C>[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:2]2[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:17]([Cl:22])[CH:16]=1

참가 물질

6

반응물 3

HCID 62657Potassium Phosphate, TribasicHCID 775784-Amino-2-chlorophenolHCID 2737170Benzoic acid, 2,4-difluoro-, ethyl ester

생성물 1

HCID 67228057Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate

시약·촉매·용매 2

HCID 8150Diglyme용매HCID 8857Ethyl Acetate용매

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온도
110 °C

실험 절차

To a solution of ethyl 2,4-difluorobenzoate (6.48 g) and 4-amino-2-chlorophenol (5.0 g) in diglyme (40 mL) was added K3PO4 (7.39 g). The mixture was stirred at 110° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated and the residue was loaded on a column and eluted with 10% ethyl acetate in hexane to give the product.

후처리

  1. washwashed with water, brine
  2. dry with materialdried over Na2SO4
  3. filtrationThe mixture was filtered
  4. customthe solvent was evaporated
  5. washeluted with 10% ethyl acetate in hexane
  6. customto give the product

출처 및 근거

ORD 기록
ord-788b9a1f586a424c98e346ebf676b9f6
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029404B2

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