Citric Acid → 1-Benzyloxycarbonyl-4-[N-(5-isoquinolinesulfonyl)tyrosyl]homopiperazine

HRID 5731

반응식

HRID 5731 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][N:14]([C:18](=[O:55])[C@H:19]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([O:41]S(C3C4C=CN=CC=4C=CC=3)(=O)=O)=[CH:37][CH:36]=2)[NH:20][S:21]([C:24]2[C:25]3[CH:26]=[CH:27][N:28]=[CH:29][C:30]=3[CH:31]=[CH:32][CH:33]=2)(=[O:23])=[O:22])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(=O)(O)[O-].[Na+]>CO.O1CCCC1>[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][N:14]([C:18](=[O:55])[C@H:19]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=2)[NH:20][S:21]([C:24]2[C:25]3[CH:26]=[CH:27][N:28]=[CH:29][C:30]=3[CH:31]=[CH:32][CH:33]=2)(=[O:22])=[O:23])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 311Citric AcidHCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 538376321-Benzyloxycarbonyl-4-[N,O-Bis(5-Isoquinolinesulfonyl)Tyrosyl]Homopiperazine

생성물 1

HCID 228421921-Benzyloxycarbonyl-4-[N-(5-isoquinolinesulfonyl)tyrosyl]homopiperazine수율 74.7%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 8028Tetrahydrofuran용매

실험 절차

5.50 g of the amorphous compound obtained in Example 122 was dissolved in 30 ml of methanol and 30 ml of tetrahydrofuran, to the solution was added 60 ml of 1N sodium hydroxide, and the mixture was refluxed for 2 hours and then cooled. The reaction mixture was acidified with citric acid and then alkalized with sodium bicarbonate, resulting insoluble matter was dissolved with a small amount of methanol, and the solution was extracted twice with 400 ml of chloroform. The extract was dried over magnesium sulfate and evaporated to remove the solvent under a reduced pressure, and resulting residue was applied to a silica gel column and eluted with chloroform/methanol (20:1) to obtain 3.1 g of the title compound in a colorless amorphous form.

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperaturecooled
  3. customresulting insoluble matter
  4. extractionthe solution was extracted twice with 400 ml of chloroform
  5. dry with materialThe extract was dried over magnesium sulfate
  6. customevaporated
  7. customto remove the solvent under a reduced pressure
  8. customresulting residue
  9. washeluted with chloroform/methanol (20:1)

출처 및 근거

ORD 기록
ord-fa570eec38af45bdaa6d75337b1e1aef
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05245034

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