Sulfoxonium, trimethyl-, iodide (1:1) → HCID 86647914, 화합물

HRID 573211노트

반응식

HRID 573211 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[I-].C[S+](C)(C)=O.C[C:19](C)([O-:21])C.[K+]>CS(C)=O>[O:21]1[C:2]2([CH2:9][CH2:8][CH2:7][CH2:6][C:5]3([O:1][CH2:10]3)[O:4][CH2:3]2)[CH2:19]1

참가 물질

5

반응물 3

HCID 74498Sulfoxonium, trimethyl-, iodide (1:1)HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 86647914HCID 86647914, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

A dimethyl sulfoxide (40 mL) solution of 1,4-dioxaspiro[4.5]decan-8-one (6.25 g) was added dropwise to a solution of trimethylsulfoxonium iodide (8.8 g) and potassium t-butoxide (4.5 g) in dimethyl sulfoxide (50 mL). The mixture was stirred at room temperature overnight. The mixture was then poured over ice-water and extracted with diethyl ether (3×200 mL). The combined organic extracts were washed with water and brine, dried over Na2SO4, and filtered. Concentration of the filtrate gave the crude product.

후처리

  1. extractionextracted with diethyl ether (3×200 mL)
  2. washThe combined organic extracts were washed with water and brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-d2e776e353b74bc795f80cca92614147
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029404B2

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