Hydrochloric Acid → HCID 178456626, 화합물

HRID 573328노트

반응식

HRID 573328 반응식
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:13]3=[N:14][CH:15]=[CH:16][CH:17]=[C:12]3[N:11]([CH:18]([CH3:20])[CH3:19])[N:10]=2)=[CH:5][CH:4]=1.Cl>CO>[CH3:20][CH:18]([N:11]1[C:12]2[C:13](=[N:14][CH:15]=[CH:16][CH:17]=2)[C:9]([C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[N:8][CH:7]=2)=[N:10]1)[CH3:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 866889833-(6-Methoxypyridin-3-yl)-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridine

생성물 1

HCID 178456626HCID 178456626, 화합물수율 80.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 3-(6-methoxypyridin-3-yl)-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridine (100 mg), MeOH (10 mL) and concentrated HCl (3 mL) was stirred at reflux for 24 h and then evaporated. The residue was treated with saturated NaHCO3 aqueous solution and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was suspended in IPE and collected by filtration to give the title compound (76 mg).

후처리

  1. temperatureat reflux for 24 h
  2. customevaporated
  3. additionThe residue was treated with saturated NaHCO3 aqueous solution
  4. extractionextracted with AcOEt
  5. dry with materialThe organic layer was dried over MgSO4
  6. concentrationconcentrated under reduced pressure
  7. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-6f510081efa34280a43c165ddab0dadb
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

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